Evidence for anti-angiogenic and pro-survival functions of the cerebral cavernous malformation protein 3

Functional analyses of human and zebrafi

Functional analyses of human and zebrafish 18–amino acid in-frame deletion pave the way for domain mapping of the cerebral cavernous malformation 3 protein

✍ Katrin Voss; Sonja Stahl; Benjamin M. Hogan; Joerg Reinders; Elisa Schleider; St 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 457 KB

Cerebral cavernous malformations (CCMs) may cause recurrent headaches, seizures, and hemorrhagic stroke and have been associated with loss-offunction mutations in CCM1/KRIT1, CCM2, and CCM3/programmed cell death 10 (PDCD10). The CCM3/PDCD10 amino acid sequence does not reveal significant homologies