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Evidence for an early appearance of modern post-switch immunoglobulin isotypes in mammalian evolution (II); cloning of IgE, IgG1 and IgG2 from a monotreme, the duck-billed platypus, Ornithorhynchus anatinus

โœ Scribed by M. Vernersson; M. Aveskogh; B. Munday; Lars Hellman


Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
561 KB
Volume
32
Category
Article
ISSN
0014-2980

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โœ Maria Aveskogh; Lars Hellman ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 672 KB

In birds, reptiles and amphibians the IgY isotype exhibits the functional characteristics of both of IgG and IgE. Hence, the gene for IgY most likely duplicated some time during early mammalian evolution and formed the ancestor of present day IgG and IgE. To address the question of when IgY duplicat