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Evidence for altered transport of insulin across the blood–brain barrier in insulin-resistant humans

✍ Scribed by Heni, Martin; Schöpfer, Patricia; Peter, Andreas; Sartorius, Tina; Fritsche, Andreas; Synofzik, Matthis; Häring, Hans-Ulrich; Maetzler, Walter; Hennige, Anita M.

Book ID
125349539
Publisher
Springer
Year
2013
Tongue
English
Weight
203 KB
Volume
51
Category
Article
ISSN
0940-5429

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## Abstract A murine monoclonal antibody (MAb) to the human insulin receptor (HIR) has been engineered for use as a brain drug delivery system for transport across the human blood–brain barrier (BBB). The HIRMAb was humanized by complementarity determining region (CDR) grafting on the framework reg