Evidence for a vesicle-mediated maintenance of store-operated calcium channels in a human embryonic kidney cell line
โ Scribed by J.M. Alderton; S.A. Ahmed; L.A. Smith; R.A. Steinhardt
- Book ID
- 114483226
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 422 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0143-4160
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An extracellular calcium (Ca 2ฯฉ o )-sensing receptor (CaR) plays crucial roles in maintaining systemic calcium homeostasis. The CaR is also expressed in other cells uninvolved in systemic mineral ion homeostasis, including keratinocytes, fibroblasts, and neurons. In brain the CaR is widely distribut
In this study we have examined the role of voltage-gated calcium channels in the regulation of calcium in juxtaglomerular cells. Using a combination of patch-clamp and single-cell calcium measurement we obtained evidence neither for voltage-operated calcium currents nor for changes of the intracellu