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Evidence for a solvent-induced change in rate-limiting step in the hydrolysis of benzaldehyde dimethyl acetal

โœ Scribed by Young, Paul R.; Bogseth, Roy C.; Rietz, Edward G.


Book ID
126408508
Publisher
American Chemical Society
Year
1980
Tongue
English
Weight
539 KB
Volume
102
Category
Article
ISSN
0002-7863

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## Abstract Recent theoretical studies of the alkaline hydrolysis of the amide bond have indicated that the nucleophilic attack of the hydroxide ion at the carbonyl carbon of the amide group is rate limiting. This is shown to be inconsistent with a large amount of experimental observations where th