✦ LIBER ✦
Evidence for a protophosphatase catalysed cleavage of adenosine triphosphate by a dissociative-type mechanism within a receptor-substrate complex
✍ Scribed by G.Michael Blackburn; Gregory R.J Thatcher; Mir Wais Hosseini; Jean-Marie Lehn
- Book ID
- 104227658
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- French
- Weight
- 307 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
WY:
Analogues of ATP and diadencsine 5',5"' -Pl,P4+etraphosphate, Ap4A, have been used to explore the specificity and mechanism of the proto-ATPase activity of the macrocyclic polyamine [241-N602 (1).
The results shcw that (1) has exonuclease-like activity and support a mechanism that is dissociative in character within a pre-associative scheme resulting fran receptor-substrate binding.