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Evidence for a pfcrt -Associated Chloroquine Efflux System in the Human Malarial Parasite Plasmodium falciparum †

✍ Scribed by Sanchez, Cecilia P.; McLean, Jeremy E.; Rohrbach, Petra; Fidock, David A.; Stein, Wilfred D.; Lanzer, Michael


Book ID
126837713
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
392 KB
Volume
44
Category
Article
ISSN
0006-2960

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Mutations in the Plasmodium falciparum pfcrt gene on chromosome 7 and possibly mutations in pfmdr1 on chromosome 5 have a role in conferring resistance against chloroquine (CQ), as do mutations of pfdhfr on chromosome 4 and pfdhps on chromosome 8 in terms of resistance against sulfadoxine/pyrimetham