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Evidence for a functional genetic polymorphism of the Rho-Gtpase Rac1: Implication in azathioprine response?

✍ Scribed by I. Billaut-Laden; J. Bourgine; A. Garat; D. Allorge; A. Crunelle-Thibaut; J. Lo-Guidice; J. Colombel; F. Broly


Book ID
116924182
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
82 KB
Volume
205
Category
Article
ISSN
0378-4274

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## Abstract **BACKGROUND:** CYP26A1, together with CYP26B1 and CYP26C1, are key enzymes of all‐__trans__ retinoic acid (RA) inactivation and their specific and restricted expression in developing embryos participate in the fine tuning RA levels. As RA is a critical regulator of gene expression duri