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Evidence for a Folded Conformation of Methotrexate in Solution

✍ Scribed by Dipl.-Chem. Peter Faupel; Prof. Dr. Volker Buss

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
244 KB
Volume
27
Category
Article
ISSN
0044-8249

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✦ Synopsis

121

The calculated isotopic shift for the PN vibration is about 4' 10 greater than the measured shift. We attribute this to an interaction between the fundamental of the stretching vibration and the overtone of the unobserved deformation vibration (Fermi resonance). Since the deformation vibration should absorb at 450cm-', on the basis of a comparison of

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