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Evidence for a differential functional regulation of the two β3-integrins αVβ3 and αIIbβ3

✍ Scribed by I.G. Ahrens; N. Moran; K. Aylward; G. Meade; M. Moser; D. Assefa; D.J. Fitzgerald; C. Bode; K. Peter

Book ID
118506345
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
766 KB
Volume
312
Category
Article
ISSN
0014-4827

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## Abstract Previous studies indicated that transfection of the platelet integrin αIIbβ3 into human melanoma cells expressing integrin αvβ3 promoted their __in vivo__ (but not __in vitro__) growth and cell survival. To reveal the underlying pathomechanism, we have analyzed the angiogenic phenotype