Evidence for a biologically active, carrier-bound form of non-suppressible insulin-like activity (nsila) in human serum
✍ Scribed by Hugh J. Cornell; Adrian C. Herington
- Book ID
- 107770377
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 635 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0020-711X
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## Abstract A factor isolated from human serum (nonsuppressible insulin‐like activity, NSILA) stimulates multiplication of serum‐starved chick embryo fibroblasts and stimulates activity of ornithine decarboxylase (ODC). Physiological doses of NSILA (200 m̈ U/ml) and pharmacological doses of insulin
## Abstract A multiplication‐stimulating activity for chicken embryo fibroblasts has been purified approximately 6000‐fold from calf serum by a three step procedure. The partially purified multiplication‐stimulating activity stimulated DNA synthesis, mitosis, and growth of cultured chicken embryo f