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Evidence for a 2,3-epoxide as an intermediate in the microsomal metabolism of benzo[a]pyrene to 3-hydroxybenzo[a] pyrene

โœ Scribed by S.K. Yang; P.P. Roller; P.P. Fu; R.G. Harvey; H.V. Gelboin


Book ID
119406439
Publisher
Elsevier Science
Year
1977
Tongue
English
Weight
375 KB
Volume
77
Category
Article
ISSN
0006-291X

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We have used the human hepatoma cell line, Hep G2, to examine the ability of hormones and xenobiotics to modulate the hepatic induction of benzo(a)pyrene hydroxylase and epoxide hydrolase. Hep G2 cells were cultured in Eagle's Minimum Essential Medium supplemented with 10% fetal calf serum. 3-Methyl