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Evidence against increased oxidative DNA-damage in Down syndrome

✍ Scribed by Rainer Seidl; Susanne Greber; Elisabeth Schuller; Günther Bernert; Nigel Cairns; Gert Lubec

Book ID
117475837
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
49 KB
Volume
235
Category
Article
ISSN
0304-3940

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## Abstract The role of histones and higher order chromatin structures in protecting against oxidative DNA damage was investigated using an in vitro system consisting of nuclear and nucleoid monolayers as model chromatin substrates. These substrates, derived from human skin fibroblasts, were challe