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Evidence against a major genetic basis for combined breast and colorectal cancer susceptibility

โœ Scribed by H Brinkman; J Barwell; S Rose; L Tinworth; N Sodha; C Langman; L Brooks; S Payne; S Fisher; A Rowan; I Tomlinson; S Hodgson

Book ID
110888287
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
80 KB
Volume
70
Category
Article
ISSN
0009-9163

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Anecdotal reports of hereditary colorectal cancer suggest that genetic anticipation (earlier appearance in successive generations) occurs, but ascertainment bias and cohort effects confound this interpretation. Using approaches that correct for such biases, we examined the age at diagnosis of colore