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Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants

✍ Scribed by Hemann, Michael T.; Bric, Anka; Teruya-Feldstein, Julie; Herbst, Andreas; Nilsson, Jonas A.; Cordon-Cardo, Carlos; Cleveland, John L.; Tansey, William P.; Lowe, Scott W.

Book ID
109894551
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
980 KB
Volume
436
Category
Article
ISSN
0028-0836

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The tumour suppressor gene, p53, plays an important role in tumour development. Under low levels of oxygen (hypoxia), cells expressing wild-type p53 undergo programmed cell death (apoptosis), whereas cells expressing mutations in the p53 gene may survive and express angiogenic growth factors that st