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Evaluation of uroprotective efficacy of amifostine against cyclophosphamide induced hemorrhagic cystitis

โœ Scribed by Srivastava, A; Nair, S C; Srivastava, V M; Balamurugan, A N; Jeyaseelan, L; Chandy, M; Gunasekaran, S

Book ID
110010893
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
140 KB
Volume
23
Category
Article
ISSN
0007-1188

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Efficacy of mesna in preventing further
Efficacy of mesna in preventing further cyclophosphamide-lnduced hemorrhagic cystitis
โœ Luce, James K. ;Simons, Jarid A. ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 217 KB

Mesna is a sulfhydryl compound that reacts with the metabolites of cyclophosphamide that are excreted in the urine and may produce bladder wall irritation. Mesna is converted in the blood to a biochemically inactive compound that is reduced back to mesna in the kidneys. In this way it has the potent