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Evaluation of two new bifunctional chelates for radiolabeling a parathyroid-specific monoclonal antibody with In-111

✍ Scribed by Schwarz, S.W.; Mathias, C.J.; Sun, J.Y.; Dilley, W.G.; Wells, S.A.; Martell, A.E.; Welch, M.J

Book ID
122718895
Publisher
Elsevier Science
Year
1991
Weight
519 KB
Volume
18
Category
Article
ISSN
0883-2897

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Monoclonal antibody 3E1.2 was coupled with the bifunctional chelate, cyclic DTPA anhydride, at molar ratios (cOTPAA:3E1.2) of 1:1, lO:l, 1OO:l and 1oOO:l. The desired substitution level of less than one mol of D"PA/bl of 3E1.2 was achieved at a molar ratio of 1O:l and a coupling efficiency of 9.9t3.