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Evaluation of tumor microsatellite instability using five quasimonomorphic mononucleotide repeats and pentaplex PCR

✍ Scribed by Nirosha Suraweera; Alex Duval; Maryline Reperant; Christelle Vaury; Daniela Furlan; Karen Leroy; Raquel Seruca; Barry Iacopetta; Richard Hamelin


Book ID
119756850
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
177 KB
Volume
123
Category
Article
ISSN
0016-5085

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✍ Jeffery W. Bacher; Wael M. Abdel Megid; Marijo G. Kent-First; Richard B. Halberg 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 234 KB

Tumors lacking DNA mismatch repair activity (MMR) from patients with Hereditary Nonpolyposis Colorectal Cancer (HNPCC) or those with sporadic colorectal cancer can be identified by the presence of high levels of instability in repetitive sequences known as microsatellites (MSI). The assessment of MS