Evaluation of Topical Application of Clobetasol 17-Propionate from Various Cream Bases

Evaluation of in vivo bioequivalence met

Evaluation of in vivo bioequivalence methodology for topical clobetasol 17-propionate based on pharmacodynamic modeling using Chinese skin

✍ Jui-Chen Tsai; Ching-Ling Cheng; Yi-Fang Tsai; Hamm-Ming Sheu; Chen-Hsi Chou 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 158 KB

The United States Food and Drug Administration recommends pilot dose duration-response and pivotal bioequivalence studies to be conducted using reflectance colorimetry for assessment of the in vivo bioequivalence of topical dermatologic corticosteroids. The major objectives of the present studies we