Polymorphisms in the human CYP1A1 gene a
β
Drakoulis, N. ;Cascorbi, I. ;BrockmοΏ½ller, J. ;Gross, C.R. ;Roots, I.
π
Article
π
1994
π
Springer-Verlag
π
English
β 940 KB
Genetic differences in the metabolism of carcinogens may codetermine individual predisposition to cancer. Cytochrome P-4501A1 (CYP1A1) metabolically activates precarcinogens in cigarette smoke, such as benzo(a)pyrene, which is also an inducer of CYP1A1. Two point mutations have been reported, ml in