Evaluation of therapeutic targets in animal models of arthritis: How does it relate to rheumatoid arthritis?

Angiotensin II type 1 receptor as a nove

Angiotensin II type 1 receptor as a novel therapeutic target in rheumatoid arthritis: In vivo analyses in rodent models of arthritis and ex vivo analyses in human inflammatory synovitis

✍ A. Price; J. C. Lockhart; W. R. Ferrell; W. Gsell; S. McLean; R. D. Sturrock 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 170 KB

## Abstract ## Objective Angiotensin II (Ang II) is known to have proinflammatory actions, and Ang II type 1 (AT~1~) receptors are up‐regulated in the rheumatoid synovium, suggesting that this receptor could be a therapeutic target. The purpose of this study was to investigate the antiinflammatory