𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Evaluation of the safety of a coumarin–troxerutin combination

✍ Scribed by Professor Rudolf Bruppacher; Bernd Rieckemann; Belal Naser-Hijazi; Peter Wüstenberg

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
102 KB
Volume
7
Category
Article
ISSN
1053-8569

No coin nor oath required. For personal study only.

✦ Synopsis

Concerns about liver reactions reported for coumarin preparations prompted a re-evaluation of the combination of coumarin with troxerutin, widely used since 1971 in Germany. No evidence of liver toxicity could be found in available clinical research data. We estimated the number of coincidental cases of unexplained clinically apparent liver disease expected to arise during the patient treatment time on the basis of sales and the maximal recommended daily dosage. A comparison to the number of spontaneous reports yielded reassuring results.

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