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Evaluation of the relationship between chemical and biological monitoring of low-level lead poisoning

✍ Scribed by Donald C. Wigfield; Sandra C. Wright; Chuni L. Chakrabarti; Regina Karwowska

Publisher: John Wiley and Sons
Year: 1986
Tongue: English
Weight: 411 KB
Volume: 6
Category: Article
ISSN: 0260-437X
DOI: 10.1002/jat.2550060402

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✦ Synopsis

Blood lead levels, together with 8-aminolevulinic acid dehydratase activity determinations have been measured on rats dosed with up to 1000 ppm lead acetate in their drinking water for periods up to 5 weeks. Despite evidence of a compensation mechanism developing in the enzyme determinations, enzyme activity ratios, if properly chosen, still correlate reasonably well ( r = 0.87) with blood lead levels. Activity ratios using data on the shoulders of pH-activity profiles (e.g. activity ratios of 6.4 and 7.2), however, give much less satisfactory correlations. These data provide a more stringent test of the chemical monitor-biological monitor correlation than has previously been possible.

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