Evaluation of the Number of Agonist Molecules Needed to Activate a Ligand-Gated Channel from the Current Rising Phase

A Novel Parameter to Estimate the Minimu

A Novel Parameter to Estimate the Minimum Number of Bound Ligands Needed to Activate an Ion Channel

✍ Tiziana Castrignanò; Filippo Aluffi-Pentini; Valerio Parisi 📂 Article 📅 1999 🏛 Elsevier Science 🌐 English ⚖ 136 KB

We consider the Hill coe$cient obtained from concentration}response curves and we stress the di!erences between the use of binding and the use of current for the response. We "rst show that in order to estimate the cooperativity of binding sites one must use the coe$cient obtained from the binding c