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Evaluation of the mutagenic and genotoxic activities of anti-hepatitis B analogs of β-l-adenosine by the Ames test and the Comet assay

✍ Scribed by L Placidi; M De Meo; G Gosselin; J.L Imbach; M.L Bryant; G Dumenil; J.P Sommadossi

Book ID
114144316
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
100 KB
Volume
50
Category
Article
ISSN
0166-3542

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## Abstract A rapid, high‐throughput bacterial mutagenicity test system has been developed (MutaGen test) that detects reversions of inactivating base‐pair substitutions and frameshifts in a TEM‐1 class A β‐lactamase (ampicillinase) gene. To quickly and sensitively detect mutagens, the system utili