Evaluation of the liver protective principles from the root of Cudrania cochinchinensis var. gerontogea
✍ Scribed by Chun-Ching Lin; Hsiang-Yu Lee; Cheng-Hsiung Chang; Tsuneo Namba; Masao Hattori
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 518 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0951-418X
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✦ Synopsis
Three components in the EtOAc and n-BuOH fractions, obtained from the ethanol extract of Cudruniu cochinchinensis var. gerontogea (Moraceae) were evaluated for their hepatoprotective activities in rats on carbon tetrachloride (CCId and D-galactosamine (D-Ga1N)-induced hepatotoxicity. Three flavonoids (25 mg/kg), wighteone, naringenin and populnin (kaempferol-7-glucoside), exhibited greater hepatoprotective effects on CC1,-induced liver injury than on D-GalN-induced hepatotoxicity by reversing the altered serum enzymes (SCOT and SGPT) and preventing the development of hepatic lesions, including liver centrilobular inflammation, cell necrosis, fatty change, ballooning degeneration in C C 4 intoxication and necrosis of the portal area in D-GalN intoxication. Wighteone and naringenin (25 mg/kg) isolated from the EtOAc fraction showed a better hepatoprotective effect against CCl,-induced liver injury than that of populnin (25 mg/kg) obtained from the n-BuOH fraction. Furthermore, wighteone protected the liver, not only against CCI,-induced hepatotoxicity, but also against D-GalN-induced liver injury. These results demonstrated that wighteone and naringenin are two active hepatoprotective principles from Cudruniu cochinchinensis var. gerontogea.