Evaluation of the Langmuir Formalism for Modeling the Adsorption Isotherms of Proteins and Polyelectrolytes in Simulations of Ion Exchange Chromatography

Mathematical modeling of elution curves

Mathematical modeling of elution curves for a protein mixture in ion exchange chromatography and for the optimal selection of operational conditions

✍ C. Shene; A. Lucero; B.A. Andrews; J.A. Asenjo 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 194 KB 👁 2 views

Elution curves in ionic exchange chromatography (IEC) for a three-protein mixture (alpha-lactoalbumin, ovalbumin, and beta-lactoglobulin), carried out under different flow rates and ionic strength conditions, were simulated using two different mathematical models. These models were the Plate Model a