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Evaluation of the Langat/dengue 4 chimeric virus as a live attenuated tick-borne encephalitis vaccine for safety and immunogenicity in healthy adult volunteers

✍ Scribed by Peter F. Wright; Sharon Ankrah; Susan E. Henderson; Anna P. Durbin; Jim Speicher; Stephen S. Whitehead; Brian R. Murphy; Alexander G. Pletnev

Book ID: 116960277
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 588 KB
Volume: 26
Category: Article
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2007.12.015

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✍ Natalia S. Pripuzova; Natalia V. Tereshkina; Larissa V. Gmyl; Tatiana I. Dzhivan 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 147 KB

## Abstract The chimeric flavivirus LGT/DEN4 containing prM and E genes of naturally attenuated Langat virus with remaining sequence derived from low neuroinvasive Dengue 4 virus was previously produced and assessed as a candidate for live vaccine against tick‐borne encephalitis (TBE) [Pletnev and