Evaluation of the jackknife technique for fitting multiexponential functions to biochemical data
✍ Scribed by I.A. Nimmo; Anne Bauermeister; J.E. Dale
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- English
- Weight
- 429 KB
- Volume
- 110
- Category
- Article
- ISSN
- 0003-2697
No coin nor oath required. For personal study only.
✦ Synopsis
The jackknife technique was tested by fitting a two-exponential function to the time course of disappearance of radioactivity from the area of a wheat leaf that had been fed %Os. The function was fitted by both unweighted and weighted least squares, first without and then with the jackknife. Weighting altered the estimates of the function's parameters, but jackknihng did not. Hence jackknifing did not remove any of the bias introduced by incorrect weighting. The confidence limits of the parameters calculated by jackknifing were greater than those estimated from the variance-covariance matrix of the regression, but sin'dar to those derived from replicate experiments. The jackknife also allowed confidence limits for the rate constants and transit time of the underlying two-compartment model to be derived.