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Evaluation of the in Vivo Biodistribution of Indium-111 and Yttrium-88 Labeled Dendrimer-1B4M-DTPA and Its Conjugation with Anti-Tac Monoclonal Antibody †

✍ Scribed by Kobayashi, Hisataka; Wu, Chuanchu; Kim, Meyoung-Kon; Paik, Chang H.; Carrasquillo, Jorge A.; Brechbiel, Martin W.

Book ID
121241561
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
152 KB
Volume
10
Category
Article
ISSN
1043-1802

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The biodistribution of indium-111/yttrium-88-labeled B3 monoclonal antibody, a murine IgG1k, was evaluated in non-tumor-bearing mice. B3 was conjugated to either 2-(p-SCN-Bz)-6-methyl-DTPA (1B4M) or 2-(p-SCN-Bz)-1,4,7,10 tetraazacyclododecane tetra-acetic acid (2B-DOTA) and labeled with 111In at 1.4