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Evaluation of the genotoxicity potential of a Nectandra membranacea extract employing in vitro micronucleous test with metabolic activation

✍ Scribed by A. Arnobio; S.R.F. Moreno; L.Q.A. Caldas

Book ID: 116924410
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 82 KB
Volume: 205
Category: Article
ISSN: 0378-4274
DOI: 10.1016/j.toxlet.2011.05.601

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Paclitaxel is a recent chemotherapeutic agent that inhibits tubulin depolymerization in tumoral cells. Despite its increasing use against various human cancers, the genotoxicity of paclitaxel has never been studied on normal human cells. The in vitro genotoxic effects of the drug were evaluated with