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Evaluation of the genotoxic potential of six triorganotin compounds by the mouse micronucleus and spermhead abnormality tests

✍ Scribed by Sam Choon Kook; Ng Meng Kwong; V G Kumar Das

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 565 KB
Volume: 5
Category: Article
ISSN: 0268-2605
DOI: 10.1002/aoc.590050507

No coin nor oath required. For personal study only.

✦ Synopsis

Six

triorganotin compounds-Ph,SnOH, BuPh,SnOH, (p-CIC6H,)Ph,SnOH, (cyclo-C5H9)Ph2SnOH, Ph3SnO2CCH2CS2NMe2 and Bu,SnOSO,Et-were tested for their mutagenic potential in somatic and germinal cells in ICR mice by using the micronucleus and spermhead abnormality assays, respectively. In somatic cells, the compounds significantly induced chromosomal disorders at half their respective estimated LD50 (i.p.) values (5.00-6.25 mg kg-' body wt), and one compound, Ph,SnOH, even at 1/20 of its estimated LD,, value. In germinal cells, five compounds significantly induced chromosomal disorders at 1/64 of their respective estimated LD50 (i.p.) values, whereas one, (p-CIC,H,)Ph,SnOH, caused such disorders only at 1/8 of its estimated LDS0 value.

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