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Evaluation of the enantioselectivity of an ovomucoid and a cellulase chiral stationary phase towards a set of β-blocking agents

✍ Scribed by C. Vandenbosch; W. Lindner; D.L. Massart

Publisher: Elsevier Science
Year: 1992
Tongue: English
Weight: 703 KB
Volume: 270
Category: Article
ISSN: 0003-2670
DOI: 10.1016/0003-2670(92)80087-n

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✦ Synopsis

The enantioselectivity of chiral stationary phases (CSP) with ovomucoid and cellulase proteins as chiral selector, towards twenty-four E-blocking agents has been evaluated. On both phases, influences of hydrophobicity, mobile phase modifier content and mobile phase pH on retention behaviour and enantioselectivity were studied. Compounds with a value of the logarithm of the partition coefficient between n-octanol and water (log P) smaller than 2, are not likely to be enantioseparated on ovomucoid. For the cellulase CSP, a correlation was found between retention behaviour and hydrophobicity. This CSP showed very good enantioselectivity towards the group of compounds / studied and a trend in higher separation coefficients for more hydrophobic compounds was observed.

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