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Evaluation of the Effect of Endothelin-1 and Characterization of the Selective Endothelin A Receptor Antagonist PD155080 in the Prostate

✍ Scribed by Imajo, Chieko; Walden, Paul D.; Shapiro, Ellen; Doherty, Annette M.; Lepor, Herbert

Book ID
123056999
Publisher
Lippincott Williams and Wilkins
Year
1997
Tongue
English
Weight
609 KB
Volume
158
Category
Article
ISSN
0022-5347

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Pharmacological characteristics of endothelin receptors in the rabbit ventricular myocardium: The nonselective endothelin receptor antagonist PD 145065 antagonizes the positive inotropic effect of endothelin-3 but not of endothelin-1
✍ Ikuo Norota; Masao Endoh πŸ“‚ Article πŸ“… 1996 πŸ› Springer 🌐 English βš– 754 KB

Endothelin-3 (ET-3) elicited a concentration-dependent positive inotropic effect on rabbit papillary muscle, the maximal response being approximately 65% of the maximal response to isoproterenol. ET-1 induced a positive inotropic effect over the concentration range below 10(-9) M, at which ET-3 did