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Evaluation of the effect of culture configuration on morphology, survival time, antioxidant status and metabolic capacities of cultured rat hepatocytes

✍ Scribed by L Richert; D Binda; G Hamilton; C Viollon-Abadie; E Alexandre; D Bigot-Lasserre; R Bars; P Coassolo; E LeCluyse

Book ID
117587480
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
858 KB
Volume
16
Category
Article
ISSN
0887-2333

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Monolayers of rat hepatocytes metabolize 0.25 mM 2acetylaminofluorene (AA F) to various ether-extractable, watersoluble as well as covalently bound products. The major ether-extractable metabolite formed is 2-aminofluorene (AF), followed by 7-OH-AAF and 9-OH-AAF. Pretreatment of rats with the induce