Evaluation of the destructive effect of khaya gum on Bacillus subtilis spores during tableting
✍ Scribed by O. A. Odeku; O. A. Itiola; H. A. Odelola
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 50 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0951-418X
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✦ Synopsis
The destructive effect of khaya gum used as a binding agent in a paracetamol formulation on Bacillus subtilis spores during tableting has been investigated, in comparison with the effects of two standard binders-polyvinylpyrrolidone and gelatin. The destructive effect of khaya gum was generally similar to those of the standard binders. Significant ( p 0.001 in each case) inverse linear relationships of log % survival of the B. subtilis spores with compression pressure and with concentration of binder, were established. The effect of the binding agent was significantly dependent ( p 0.001 in each case) on both compression pressure and the binder concentration. However, there was no significant interaction ( p b 0.05) between the destructive effects of compression pressure and binder concentration. The results suggest that khaya gum and the standard binders would be useful in the destruction of microorganisms during tableting.