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Evaluation of the CNS properties of SCH 29851, a potential non-sedating antihistamine

✍ Scribed by A. Barnett; L. C. Iorio; W. Kreutner; S. Tozzi; H. S. Ahn; A. Gulbenkian


Book ID
105427503
Publisher
SP Birkhäuser Verlag Basel
Year
1994
Tongue
English
Weight
736 KB
Volume
43
Category
Article
ISSN
1420-908X

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Recent in vitro studies have suggested that P-glycoprotein (Pgp) and passive membrane permeability may influence the brain concentrations of non-sedating (second-generation) antihistamines. The purpose of this study was to determine the importance of Pgp-mediated efflux on the in vivo brain distribu