Evaluation of the annual killifish Nothobranchius guentheri as a tool for rapid acute toxicity screening
✍ Scribed by Tommy R. Shedd,; Mark W. Widder; Margaret W. Toussaint; Mark C. Sunkel; Eugene Hull
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 59 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0730-7268
No coin nor oath required. For personal study only.
✦ Synopsis
This study evaluated the use of Nothobranchius guentheri as a novel organism for rapid acute toxicity screening. A major advantage of the species is that there is no need to maintain a continuous culture to have organisms immediately available for testing. Rather, the embryos are viable under long-term storage conditions and can be hatched within a few hours. The tests require only 24 h with standard laboratory equipment. Sensitivity levels for 11 representative toxicants were comparable to those reported for five of the standard U.S. Environmental Protection Agency test species requiring continuous culture.