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Evaluation of the Akt kinase activation in a PTEN deficient canine osteosarcoma cell line

โœ Scribed by N. G. Dervisis; B. E. Kitchell

Book ID
111219975
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
109 KB
Volume
2
Category
Article
ISSN
1476-5810

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Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC
โœ Daphne Haas-Kogan; Noga Shalev; Michelle Wong; Gordon Mills; Garret Yount; David ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 294 KB

## Glioblastomas are highly malignant tumors of the central nervous system that are resistant to radiation and chemotherapy [1]. We explored the role of the phosphatidylinositol (PI) 3-kinase signal transduction pathway in glioblastomas, as this pathway has been shown to inhibit apoptosis induced b