The effect of selected aerosol products and fluorinated hydrocarbon propellants on the heart rate and respiration of rats was determined in whole body exposure chambers by biotelemetry. Electrocardiogram and respiratory transmitters were used to broadcast selected FM signals to a nearby receiver and physiological recorder for visual display. Each rat was subjected to a single 360-min exposure of the aerosol product or propellant, kept under observation for toxicological responses, and then examined for histopathological signs of toxicity. The fluoroalkane propellants used depressed the heart rate in high concentrations. First degree atrioventricular block and T wave inversion were also observed in some animals. The propellants tested also had a depressant effect on respiratory rate and minute volume. The selected aerosol product produced similar effects but a t concentrations much higher than would be experienced during normal consumer use. Histopathological examination revealed greater tissue damage with the aerosol product than with the propellants alone. The cardiac and respiratory abnormalities occurred only after exposure to high concentrations of the fluoroalkane propellants. Also, the pathology report gave no indication of the existence of "thesaurosis" or pulmonary granulomatosis.
Keyphrases 0 Telemetry-evaluation as technique for determining toxicity of aerosol preparations Toxicity, aerosols-evaluation of telemetry as technique for determination Aerosolsevaluation of telemetry for determining toxicity Propellants, aerosols-evaluation of telemetry for determining toxicity Fluorinated hydrocarbons-use of telemetry in evaluating toxicity of aerosol preparations ' Chlorhydrol, Impalahle,