Evaluation of systemic chemotherapy with methotrexate, vinblastine, Adriamycin, and cisplatin for advanced bladder cancer
โ Scribed by Toshihiko Kotake; Hideyuki Akaza; Shigoe Isaka; Susumu Kagawa; Kenkichi Koiso; Toyohei Machida; Akio Maru; Yosuke Matsumura; Ikuo Miyagawa; Tadao Niijima; Koji Obata; Yasuo Ohashi; Hiroshi Ohe; Yoshitada Ohi; Eigoro Okajima; Yasunosuke Sakata; Jun Shimazaki; Kazuya Tashiro; Masaki Togashi; Toyofumi Ueda; Takeshi Uyama; Kazuyuki Yoshikawa
- Publisher
- Springer
- Year
- 1992
- Tongue
- English
- Weight
- 469 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0344-5704
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Background. A Phase I1 trial with a new regimen of methotrexate, carboplatin, and vinblastine (M-CAVI) was conducted for patients with bladder cancer who could not receive cisplatin-based chemotherapy. Methods. Treatment consisted of methotrexate (30 mg/m2) on days 1,15, and 22; carboplatin (300 mg
One hundred ninety-one patients with recurrent or metastatic squamous cell carcinoma of head and neck origin were allocated at random to chemotherapy with conventional-dose weekly intravenous methotrexate or the combination of cisplatin, vinblastine, and bleomycin. Methotrexate induced responses in