Evaluation of substrates for 90° peel adhesion—A collaborative study. II. Transdermal drug delivery systems

✍ Scribed by Anna M. Wokovich; Stanley A. Brown; Meiyu Shen; William H. Doub; Bing Cai; Nakissa Sadrieh; Mei Ling Chen; Stella Machado; Lucinda F. Buhse

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 89 KB
• Volume: 88B
• Category: Article
• ISSN: 1552-4973
• DOI: 10.1002/jbm.b.31149

✦ Synopsis

Abstract

In a previous study on peel adhesion for medical tapes, it was shown that a stainless steel (SS) substrate better discriminated among medical tapes than a high‐density polyethylene (HDPE) substrate. The objective of this study was to determine if a SS substrate would also better distinguish among transdermal drug delivery systems (TDDSs). Five TDDSs (Vivelle Dot®, Climara®, Catapres‐TTS®, Duragesic®, and Mylan Fentanyl) were evaluated on three different substrates (SS, HDPE, and human cadaver skin). All measurements were made using a dwell time of ∼3 min, a peel angle of 90°, and a peel speed of 300 mm/min. Differences among TDDSs were greater for SS than for HDPE, using the F statistic for testing for differences among TDDSs means as a measure of heterogeneity, thereby indicating greater discrimination by SS. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009