Systematic evaluation of objective funct
Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli
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Schuetz, Robert; Kuepfer, Lars; Sauer, Uwe
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Article
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2007
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Nature Publishing Group
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English
β 278 KB
To which extent can optimality principles describe the operation of metabolic networks? By explicitly considering experimental errors and __in silico__ alternate optima in flux balance analysis, we systematically evaluate the capacity of 11 objective functions combined with eight adjustable constrai