## Background: It has been estimated that the prevalence of carriers of a mutated mismatch repair (mmr) gene among the general population in western countries is between 5 and 50 per 10,000. these carriers have a risk of >85% of developing colorectal carcinoma (crc) and therefore need careful follo
Evaluation of screening strategy for detecting hereditary nonpolyposis colorectal carcinoma
β Scribed by Taiji Furukawa; Fumio Konishi; Kazuhisa Shitoh; Masayuki Kojima; Hideo Nagai; Toshihiko Tsukamoto
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 98 KB
- Volume
- 94
- Category
- Article
- ISSN
- 0008-543X
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In hereditary nonpolyposis colorectal cancer (HNPCC), the majority of reported mutations are dispersed throughout the 35 exons of the two principal susceptibility genes, MLH1 and MSH2, and because of this complexity, rapid mutation screening methods are required. The aim of this study was to evaluat
## Background: Germline mutations in the dna mismatch repair genes, msh2, mlh1, and others are associated with hereditary nonpolyposis colorectal cancer (hnpcc). due to the high costs of sequencing, cheaper screening methods are needed to identify hnpcc cases. ideally, these methods should have a h
## Abstract ## BACKGROUND Prevention benefits from predictive genetic testing for cancer will only be fully realized if appropriate screening is adopted after testing. The current study assessed screening and preventive behaviors during 12 months after predictive genetic testing for hereditary non
## Background: Molecular testing for hereditary nonpolyposis colorectal carcinoma (hnpcc) is becoming standard care and it is cost-effective compared with no genetic testing. however, the best strategy for detection of hnpcc gene carriers is unknown. ## Methods: We use a decision analytic model t