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Evaluation of scaffold materials for tooth tissue engineering

✍ Scribed by Takayuki Ohara; Toshimitsu Itaya; Kazutada Usami; Yusuke Ando; Hiroya Sakurai; Masaki J. Honda; Minoru Ueda; Hideaki Kagami

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
393 KB
Volume
9999A
Category
Article
ISSN
1549-3296

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✦ Synopsis

Abstract

Recently, the possibility of tooth tissue engineering has been reported. Although there are a number of available materials, information about scaffolds for tooth tissue engineering is still limited. To improve the manageability of tooth tissue engineering, the effect of scaffolds on in vivo tooth regeneration was evaluated. Collagen and fibrin were selected for this study based on the biocompatibility to dental papilla‐derived cells and the results were compared with those of polyglycolic acid (PGA) fiber and β‐tricalcium phosphate (β‐TCP) porous block, which are commonly used for tooth, dentin and bone tissue engineering. Isolated porcine tooth germ‐derived cells were seeded onto one of those scaffolds and transplanted to the back of nude mice. Tooth bud‐like structures were observed more frequently in collagen and fibrin gels than on PGA or β‐TCP, while the amount of hard tissue formation was less. The results showed that collagen and fibrin gel support the initial regeneration process of tooth buds possibly due to their ability to support the growth of epithelial and mesenchymal cells. On the other hand, maturation of tooth buds was difficult in fibrin and collagen gels, which may require other factors. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2010

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