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Evaluation of rat kidney aldose reductase inhibitory activity of someN-acetyl dehydroalanine derivatives

✍ Scribed by Net Das-Evcimen; Mutlu Sarikaya; Gokce Gurkok; Sibel Suzen

Book ID
105771097
Publisher
Springer-Verlag
Year
2010
Tongue
English
Weight
863 KB
Volume
20
Category
Article
ISSN
1054-2523

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A number of N-benzenesulfonylglycines, alanines, sarcosine, and prolines, which contain the minimum pharmacophore moieties necessary for aldose reductase inhibitory activity, were prepared and tested in the rat lens assay. In this assay, the benzenesulfonylglycines are considerably more potent than