Evaluation of procoagulant activity production and other coagulative functions in cancer patients receiving acid treatedSalmonella minnesotaR 595 (Re)
✍ Scribed by G. Miragliotta; G. Vagno; R. Nappi; D. Fumarola; E. Jirillo; C. Galanos
- Book ID
- 104642553
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 384 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0393-2990
No coin nor oath required. For personal study only.
✦ Synopsis
Blood clotting parameters were measured in six patients with gynecologic tumors following i.v. administration of acetic acid-treated Salmonella minnesota R595 (Re), which has been previously demonstrated to enhance impaired immune functions in the same patients. Although these bacteria possess a more .exposed lipid A at their surface which has the potential to stimulate the coagulative cascade, no evidence of plasma hypercoagulative state was detected. In fact, procoagulant activity generated by patients' mononuclear cells after Salmonella treatment was not significantly higher than that produced by patients' cells before treatment. Moreover, other haernostatic laboratory parameters were unaffected by in vivo treatment with bacteria.