Evaluation of pretreatment computed tomography as a predictor of local control in T1/T2 pyriform sinus carcinoma treated with definitive radiotherapy
✍ Scribed by Frank A. Pameijer; Anthony A. Mancuso; William M. Mendenhall; James T. Parsons; Suresh K. Mukherji; Robert Hermans; Paul S. Kubilis
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 267 KB
- Volume
- 20
- Category
- Article
- ISSN
- 1043-3074
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✦ Synopsis
Background:
This study was undertaken to determine whether pretreatment computed tomography (ct) findings can predict local control in pyriform sinus carcinoma treated with definitive radiotherapy (rt).
Methods:
Twenty-three patients with pyriform sinus carcinoma (t1: n = 5; t2: n = 18) were treated with high-dose rt and followed for a minimum of 2 years. tumor volumes and extent were determined on pretreatment ct studies. the specific ct parameters assessed were analyzed as predictors of local control.
Results:
There was a significant decrease in local control rate for tumors over 6.5 ml (1 of 4 [25%]) relative to tumors under 6.5 ml (17 of 19 [89%]; p = .021). sensitivity and specificity for local control using this cutoff were 94% and 60%, respectively. tumor score, as a measure of anatomic extent, was also found to be a significant predictor of local control (p = .033). the local control rate was not influenced significantly by the presence of "minimal" apex disease (< 10 mm in greatest dimensions as measured on ct) but decreased significantly when "bulk" apex disease (> or = 10 mm) was present (p = .027). laryngeal cartilage sclerosis was not a significant predictor of outcome.
Conclusion:
Computed tomography can stratify pyriform sinus carcinomas into groups more or less likely to be locally controlled with definitive rt.