Evaluation of preparative high performance liquid chromatography and cryoprobe-nuclear magnetic resonance spectroscopy for the early quantitative estimation of drug metabolites in human plasma

The use of preparative high performance

The use of preparative high performance liquid chromatography with tandem mass spectrometric directed fraction collection for the isolation and characterisation of drug metabolites in urine by nuclear magnetic resonance spectroscopy and liquid chromatography/sequential mass spectrometry

✍ R. S. Plumb; J. Ayrton; G. J. Dear; B. C. Sweatman; I. M. Ismail 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 195 KB 👁 2 views

Preparative high performance liquid chromatography (HPLC) coupled to tandem mass spectrometry has been used successfully for the isolation of several drug metabolites from urine. Nuclear magnetic resonance (NMR) spectroscopy has been employed to determine the exact chemical structure of these metabo

Isolation of circulating metabolites in

Isolation of circulating metabolites in drug discovery using high-performance liquid chromatography, and their identification by liquid chromatography coupled with tandem mass spectrometry and nuclear magnetic resonance spectroscopy

✍ Hong Kim; Wenqing Feng; Tze-Ming Chan; Diane Rindgen; Matthew Bryant; Kathleen A 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 221 KB 👁 3 views

Isolation of circulating metabolites in drug discovery using high-performance liquid chromatography, and their identification by liquid chromatography coupled with tandem mass spectrometry and nuclear magnetic resonance spectroscopy One of the major components of modern drug discovery is the structu

Mass spectrometrically detected directly

Mass spectrometrically detected directly coupled high performance liquid chromatography/nuclear magnetic resonance spectroscopy/mass spectrometry for the identification of xenobiotic metabolites in maize plants

✍ Nigel J. C. Bailey; Paul D. Stanley; Stephen T. Hadfield; John C. Lindon; Jeremy 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 89 KB 👁 2 views

Reconstructed ion chromatograms have been used to identify relevant high performance liquid chromatography (HPLC) peaks in a directly coupled high performance liquid chromatography/nuclear magnetic resonance spectroscopy/mass spectrometry (HPLC/NMR/MS) experiment. This has been applied to a study of

The application of high performance liqu

The application of high performance liquid chromatography, coupled to nuclear magnetic resonance spectroscopy and mass spectrometry (HPLC-NMR-MS), to the characterisation of ibuprofen metabolites from human urine

✍ E. Clayton; S. Taylor; B. Wright; I. D. Wilson 📂 Article 📅 1998 🏛 Springer 🌐 English ⚖ 529 KB

Analytical procedure for the determinati

Analytical procedure for the determination of the new antitumour drug N-benzoylstaurosporine and three potential metabolites in human plasma by reversed-phase high-performance liquid chromatography

✍ R. van Gijn; O. van Tellingen; J.J.M. de Clippeleir; M.J.X. Hillebrand; E. Boven 📂 Article 📅 1995 🏛 Elsevier Science ⚖ 468 KB

Quantitative analysis of the novel antic

Quantitative analysis of the novel anticancer drug ABT-518, a matrix metalloproteinase inhibitor, plus the screening of six metabolites in human plasma using high-performance liquid chromatography coupled with electrospray tandem mass spectrometry

✍ E. Stokvis; H. Rosing; M. Crul; M. J. Rieser; A. J. R. Heck; J. H. M. Schellens; 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 245 KB 👁 2 views

## Abstract A liquid chromatographic/tandem mass spectrometric (LC/MS/MS) assay for the quantitative analysis of the novel anticancer drug ABT‐518 and the screening of six potential metabolites in human plasma has been developed and validated to support a phase I study with the drug. ABT‐518 is an