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Evaluation of predictive models for stable solid solution formation

✍ Scribed by Jessica Albers; Karin Matthée; Klaus Knop; Peter Kleinebudde

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
300 KB
Volume
100
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.

✦ Synopsis

The objective of this study was to evaluate predictive models for stable solid solution formation and to find a quick and successful approach for miscibility screenings. The results show that the interpretation of the chemical structure and the crystallinity by X-ray powder diffraction measurements as well as the determination of melting point depressions and melting enthalpies are beneficial tools to predict the miscibility of drugs and carriers. A combined approach of prediction tools is highly appropriate, as no single technique may yield all the required information. Nevertheless, the evaluation of the melting behavior via differential scanning calorimetry has the highest impact.

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